Nirogacestat
  • 化学数据
CAS号 1290543-63-3 货号 BCP24479
中文名 Nirogacestat
英文名 Nirogacestat
中文别名
英文别名 PF-03084014; PF03084014; PF 03084014; PF-3084014; PF3084014; PF 3084014;
分子式 C27H41F2N5O 分子量 489.64
  • 用途
生物活性 Nirogacestat is a selective gamma secretase (GS) inhibitor with potential antitumor activity. Nirogacestat binds to GS, blocking proteolytic activation of Notch receptors; Notch signaling pathway inhibition may follow, which may result in the induction of apoptosis in tumor cells that overexpress Notch. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth and survival.
信号通路 Protease/Metabolic Enzyme Neuro Signaling Pathway Wnt/Stem Cell 
靶 点 Gamma secretase  

结构式

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