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| CAS号 | 1290543-63-3 | 货号 | BCP24479 |
| 中文名 | Nirogacestat | ||
| 英文名 | Nirogacestat | ||
| 中文别名 | |||
| 英文别名 | PF-03084014; PF03084014; PF 03084014; PF-3084014; PF3084014; PF 3084014; | ||
| SMILES | CCCC(C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)NC2CCC3=C(C2)C(=CC(=C3)F)F | ||
| 化学名称 | |||
| 分子式 | C27H41F2N5O | 分子量 | 489.64 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Nirogacestat is a selective gamma secretase (GS) inhibitor with potential antitumor activity. Nirogacestat binds to GS, blocking proteolytic activation of Notch receptors; Notch signaling pathway inhibition may follow, which may result in the induction of apoptosis in tumor cells that overexpress Notch. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth and survival. | ||
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