Guadecitabine sodium
  • 化学数据
CAS号 929904-85-8 货号 BCP24636
中文名 Guadecitabine sodium
英文名 Guadecitabine sodium
中文别名
英文别名 SGI110; SGI-110; SGI 110; S110;SGI-110 sodium；S-110 sodium;
分子式 C18H23N9NaO10P 分子量 579.39
  • 用途
生物活性 Guadecitabine, aslo known as SGI-110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine.
信号通路 Epigenetics 
靶 点 DNA Methyltransferase 

结构式

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