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| CAS号 | 929904-85-8 | 货号 | BCP24636 |
| 中文名 | Guadecitabine sodium | ||
| 英文名 | Guadecitabine sodium | ||
| 中文别名 | |||
| 英文别名 | SGI110; SGI-110; SGI 110; S110;SGI-110 sodium；S-110 sodium; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C18H23N9NaO10P | 分子量 | 579.39 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Guadecitabine, aslo known as SGI-110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine. | ||
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