MK-4101
  • 化学数据
CAS号 935273-79-3 货号 BCP18385
中文名 MK-4101
英文名 MK-4101
中文别名
英文别名 MK4101;MK 4101;
分子式 C24H24F5N5O 分子量 493.47
  • 用途
生物活性 MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. MK-401 Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. MK-4101 showed anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells. MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1(+/-) mice. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1 MK-4101 also induced deregulation of cell cycle and block of DNA replication in tumors.
信号通路 GPCR/G Protein Wnt/Stem Cell 
靶 点 Smoothened/Smo Hedgehog 

结构式

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