Olumacostat glasaretil
| CAS号 | 1261491-89-7 | 货号 | BCP25136 |
| 中文名 | Olumacostat glasaretil | ||
| 英文名 | Olumacostat glasaretil | ||
| 中文别名 | |||
| 英文别名 | DRM01B; DRM-01B; DRM 01B; | ||
| 分子式 | C26H43NO7 | 分子量 | 481.62 |
| 生物活性 | Olumacostat glasaretil or OG is an acetyl-CoA carboxylase inhibitor. OG inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears. OG is a pro-drug of the ACC inhibitor 5-(tetradecyloxy)-2-furoic acid (TOFA) and was designed to enhance delivery in vivo. Topical application of OG but not TOFA significantly reduced hamster ear sebaceous gland size indicating that this pro-drug approach was critical to obtain the desired activity in vivo. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | ACC | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！