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| CAS号 | 1261491-89-7 | 货号 | BCP25136 |
| 中文名 | Olumacostat glasaretil | ||
| 英文名 | Olumacostat glasaretil | ||
| 中文别名 | |||
| 英文别名 | DRM01B; DRM-01B; DRM 01B; | ||
| SMILES | O=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)OCC(N(CC(OCC)=O)C)=O | ||
| 化学名称 | |||
| 分子式 | C26H43NO7 | 分子量 | 481.62 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Olumacostat glasaretil or OG is an acetyl-CoA carboxylase inhibitor. OG inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears. OG is a pro-drug of the ACC inhibitor 5-(tetradecyloxy)-2-furoic acid (TOFA) and was designed to enhance delivery in vivo. Topical application of OG but not TOFA significantly reduced hamster ear sebaceous gland size indicating that this pro-drug approach was critical to obtain the desired activity in vivo. | ||
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