MK-2206
| CAS号 | 1032349-93-1 | 货号 | BCP20200 |
| 中文名 | MK-2206 | ||
| 英文名 | MK-2206 | ||
| 中文别名 | |||
| 英文别名 | MK 2206;MK2206; | ||
| 分子式 | C25H21N5O | 分子量 | 407.48 |
| 生物活性 | MK-2206 is an allosteric inhibitor of Akt that prevents translocation of Akt to membranes. It is also an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B). It binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. It has potential antineoplastic activity. It exhibits anticancer chemotherapeutic activity in a variety of in vitro cancer models. It induces G1-phase cell cycle arrest in hepatocellular carcinoma cells, inhibits cell proliferation in non-small cell lung cancer cells, and inhibits proliferation in medullary thyroid cancer cells. It also inhibits tumor growth in animal models of nasopharyngeal cancer. | ||
| 上下游产品 | 1032350-13-2（MK-2206 2HCl） | ||
| 信号通路 | PI3K/Akt/mTOR | ||
| 靶 点 | AKT | ||
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Silencing KIF14 reverses acquired resistance to sorafenib in hepatocellular carcinoma
购于瀚香生物(Biochempartner)的MK-2206(CAS:1032349-93-1)被引用 |
结构式
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