Tebanicline HCl

CAS No.	203564-54-9	Cat. No.	BCP25177
Name	Tebanicline HCl
Synonyms	Tebanicline hydrochloride;ABT594 HCl;Tebanicline; ABT-594; ABT 594; ABT594; Ebanicline;
Formula	C9H12Cl2N2O	M. Wt	235.11

Description	Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM.Tebanicline, also known as ABT-594 and Ebanicline, a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound. It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes.
Related Products	198283-74-8（Tebanicline tosylate） 209326-18-1（Tebanicline dihydrochloride） 209326-18-1（Tebanicline benzoate） 198283-73-7（Tebanicline）
Pathways	Neuro Signaling Pathway
Targets	nAChR

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