CEP-32496 free base
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1188910-76-0 | Cat. No. | BCP16304 |
| Name | CEP-32496 free base | ||
| Synonyms | RXDX-105; RXDX 105; RXDX105; CEP32496; CEP-32496; CEP 32496; AC013773; AC 013773; AC-013773; Agerafenib; | ||
| SMILES | O=C(NC1=NOC(C(C)(C)C(F)(F)F)=C1)NC2=CC=CC(OC3=C(C=C(OC)C(OC)=C4)C4=NC=N3)=C2 | ||
| Chemical Name | |||
| Formula | C24H22F3N5O5 | M. Wt | 517.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Agerafenib, also known as RXDX-105, CEP-32496 and AC013773, is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity. CEP-32496 specifically and selectively inhibits the activity of the mutated form (V600E) of B-raf kinase. This inhibits the activation of the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway and may result in a decrease in the proliferation of tumor cells expressing the mutated B-raf gene. | ||
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