BMN-673 8R,9S
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1207456-00-5 | Cat. No. | BCP11682 |
| Name | BMN-673 8R,9S | ||
| Synonyms | (8R,9S)-BMN-673;BMN673 (8R,9S);BMN 673 (8R,9S);Talazoparib (8R,9S); | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H14F2N6O | M. Wt | 380.35 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. | ||
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