CEP-32496 hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1227678-26-3 | Cat. No. | BCP06954 |
| Name | CEP-32496 hydrochloride | ||
| Synonyms | CEP 32496 hydrochloride;CEP32496 hydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H23ClF3N5O5 | M. Wt | 553.92 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CEP-32496 is a potent BRAF inhibitor in an in vitro binding assay for mutated BRAF(V600E) (K(d) BRAF(V600E) = 14 nM) and in a mitogen-activated protein (MAP)/extracellular signal-regulated (ER) kinase (MEK) phosphorylation (pMEK) inhibition assay in human melanoma (A375) and colorectal cancer (Colo-205) cell lines (IC(50) = 78 and 60 nmol/L). In vitro, CEP-32496 has multikinase binding activity at other cancer targets of interest; however, it exhibits selective cellular cytotoxicity for BRAF(V600E) versus wild-type cells. | ||
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