BMS-852927
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1256918-39-4 | Cat. No. | BCP23542 |
| Name | BMS-852927 | ||
| Synonyms | BMS 852927; BMS852927; XL041; XL-041; XL 041; | ||
| SMILES | OC(C)(C)C1=CN(C2=CC=C(C3=CC(S(=O)(C)=O)=C(CO)C(F)=C3)C=C2F)C(C(C)(C4=C(Cl)C=CC=C4Cl)C)=N1 | ||
| Chemical Name | |||
| Formula | C29H28Cl2F2N2O4S | M. Wt | 609.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BMS-852927, also known as XL041, is a LXR partial agonist. BMS-852927 shows LXRbeta/LXRalpha: 88%/20% activity; hWBA ABCA1 EC50 = 9 nM (26%); hWBA ABCG1 EC50 = 10 nM (33%); Binding alpha1-AGP = 97.3%. BMS-852927 induces ABCA1 and ABCG1 RCT targets in human whole blood at nanomolar drug exposures with robust LXRβ agonism and limited LXRα agonist activity. BMS-852927 is LXRβ-selective compound, had favorable profiles in animal models with a wide therapeutic index in cynomolgus monkeys and mice. | ||
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