RGX-104 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP31854CAS No. ：610318-54-2Purity：98%

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CAS No.	610318-54-2	Cat. No.	BCP31854
Name	RGX-104
Synonyms	RGX104; RGX 104; SB742881; SB-742881; SB 742881;
SMILES	CC(CCOC1=CC=CC(=C1)CC(=O)O)N(CC2=C(C(=CC=C2)C(F)(F)F)Cl)CC(C3=CC=CC=C3)C4=CC=CC=C4
Chemical Name
Formula	C34H33ClF3NO3	M. Wt	596.09
Purity	98%	Storage	Store at 4-8°C
Description	RGX-104 is a liver X receptor beta agonist with potential immunomodulating and antineoplastic activities. Upon oral administration, RGX-104 selectively targets and binds to LXRbeta, thereby activating LXRbeta-mediated signaling, leading to the transcription of certain tumor suppressor genes and the downregulation of certain tumor promoter genes. This particularly activates the expression of apolipoprotein E (ApoE), a tumor suppressor protein, in tumor cells and certain immune cells. This activates the innate immune system, resulting in depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumor cells and endothelial cells in the tumor microenvironment. This reverses immune evasion, enhances anti-tumor immune responses and inhibits proliferation of tumor cells.