Pyrotinib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP29458CAS No. ：1269662-73-8Purity：98%

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CAS No.	1269662-73-8	Cat. No.	BCP29458
Related Products	1397922-61-0（Pyrotinib maleate） 1246089-97-3（Pyrotinib Racemate）
Name	Pyrotinib
Synonyms	SHR-1258; SHR1258; SHR 1258;
SMILES	O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)C2=C1)/C=C/[C@@H]5N(C)CCC5
Chemical Name
Formula	C32H31ClN6O3	M. Wt	583.08
Purity	98%	Storage	Store at 4-8°C
Description	Pyrotinibm, also known as SHR-1258, is an orally bioavailable, dual kinase inhibitor of the epidermal growth factor receptor (EGFR or HER-1) and the human epidermal growth factor receptor 2 (ErbB2 or HER-2), with potential antineoplastic activity. Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. EGFR and HER2 are receptor tyrosine kinases that are upregulated in various tumor cell types and play major roles in tumor cell proliferation and tumor vascularization.