Epertinib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 908305-13-5 | Cat. No. | BCP29362 |
| Name | Epertinib | ||
| Synonyms | S-222611; S222611; S 222611; | ||
| SMILES | CC#CC(=NOCC1COCCN1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl | ||
| Chemical Name | |||
| Formula | C30H27ClFN5O3 | M. Wt | 560.02 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Epertinib, also known as S-222611, is an oral reversible dual tyrosine kinase inhibitor of EGFR and HER2, currently under trials in patients with solid tumours. S-222611 selectively inhibited kinases with IC50 s below 10 nmol/L. S-222611 also inhibited intracellular kinase activity and the growth of EGFR-expressing and HER2-expressing cancer cells. In addition, S-222611 showed potent antitumor activity over lapatinib in a variety of xenograft models. | ||
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