PLX-8394
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1393466-87-9 | Cat. No. | BCP19619 |
| Name | PLX-8394 | ||
| Synonyms | PLX 8394;PLX8394;Plixorafenib; | ||
| SMILES | O=C(C1=C(F)C(NS(=O)(N2CC[C@@H](F)C2)=O)=CC=C1F)C3=CNC4=C3C=C(C=N4)C5=CN=C(C6CC6)N=C5 | ||
| Chemical Name | |||
| Formula | C25H21F3N6O3S | M. Wt | 542.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PLX8394 is an orally bioavailable inhibitor of serine/threonine-protein kinase B-raf (BRAF) protein with potential antineoplastic activity. PLX8394 appears to selectively bind to and inhibit the activity of both wild-type and mutated forms of BRAF, which may subsequently inhibit the proliferation of tumor cells which express mutated forms of BRAF. PLX8394 appears to be effective against tumors that express multiple mutated forms of the kinase and may be an effective therapeutic agent for tumors that are resistant to other BRAF inhibitor therapies that are specific for the BRAF V600E mutant. | ||
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