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LY-3009120 Chemical Structure

LY-3009120

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP23869CAS No. ：1454682-72-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1454682-72-4 Cat. No. BCP23869
Name LY-3009120
Synonyms LY3009120; LY 3009120; DP4978; DP 4978; DP-4978;
SMILES
Chemical Name
Formula C23H29FN6O M. Wt 424.51
Purity 98% Storage Store at 4-8°C
Description LY3009120, also known as DP-4978, is potent and selective pan-RAF inhibitor with potential anticancer activity. LY3009120 showed activities against BRaf or Ras mutant tumor cells . LY3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY3009120 inhibits MEK phosphorylation and cell proliferation in vitro, and exhibits anti-tumor activity in multiple xenograft models carrying mutations in BRaf, NRas or KRas.
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