L-733060 hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 148687-76-7 | Cat. No. | BCP49092 |
| Name | L-733060 hydrochloride | ||
| Synonyms | L-733,060; L733,060; L 733,060; L-733060; L733060; L 733060; L-733060 HCl salt; | ||
| SMILES | C1CC(C(NC1)C2=CC=CC=C2)OCC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F.Cl | ||
| Chemical Name | |||
| Formula | C20H20ClF6NO | M. Wt | 439.82 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | L-733,060 is an orally active, non-peptide, selective antagonist for the NK1 receptor, binding with a Ki of 0.08nM. L-733,060 has antidepressant and anxiolytic effects in animal studies, and reduces both the dopamine release and neurotoxicity produced by methamphetamine and cocaine. It shows antiinflammatory and anti-hepatotoxic effects in animals, and counteracts the development of hyperalgesia following nerve injury.[15][16] It also has anticancer effects in a variety of in vitro models. | ||
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