Iniparib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01784CAS No. ：160003-66-7Purity：98%

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CAS No.	160003-66-7	Cat. No.	BCP01784
Name	Iniparib
Synonyms	BSI-201;SAR-240550;IND7-677;BSI 201;SAR 240550;IND 71677;
SMILES
Chemical Name
Formula	C7H5IN2O3	M. Wt	292.03
Purity	98%	Storage	Store at 4-8°C
Description	BSI-201 is described as a prodrug of 4-iodo-3-nitrosobenzamide, an agent that covalently inhibits PARP1 by binding to its first zinc finger under cell-free conditions. Treatment of 120 μM BSI-201 plus buthionine sulfoximine (BSO) induces a 95% cell death among 855-2 cells, and displays a similar effect in other human cancer cells. BSI-201 inhibits the growth of E-ras 20 cells, the effect of which can be augmented 4-fold when BOS is added. Recently BSI-201 shows no ability to inhibit PARP enzymatic or cellular activity, but can non-selectively modify cysteine-containing proteins in tumor cells, suggesting the mechanism of action for BSI-201 is likely not via inhibition of PARP activity. BSI-201 (100 μM) inhibits ionizing radiation-induced single-strand breaks (SSBs) repair in human lymphoid cell lines based on large endogenous Epstein–Barr virus (EBV) circular episomes assay, resulting in 55% repair by 2 hours, which can be reversed surprisingly by knockdown of PARP1, indicating that th