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Glumetinib Chemical Structure

Glumetinib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP31155CAS No. :1642581-63-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1642581-63-2 Cat. No. BCP31155
Name Glumetinib
Synonyms SCC244; SC-C244; SCC 244;
SMILES CN1C=C(C=N1)C2=CN3C(=NC=C3S(=O)(=O)N4C5=C(C=N4)N=CC(=C5)C6=CN(N=C6)C)C=C2
Chemical Name
Formula C21H17N9O2S M. Wt 459.49
Purity 98% Storage Store at 4-8°C
Description Glumetinib is a novel, potent and highly selective inhibitor of c-Met in MET-dependent cancer models. SCC244 showed subnanomolar potency against c-Met kinase activity and high selectivity versus 312 other tested protein kinases, making it one of the most selective c-Met inhibitors described to date. Moreover, this inhibitor profoundly and specifically inhibits c-Met signal transduction and thereby suppresses the c-Met-dependent neoplastic phenotype of tumor and endothelial cells.
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