Aprepitant New
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| CAS No. | 170729-80-3 | Cat. No. | BCP02095 |
| Name | Aprepitant | ||
| Synonyms | MK-0869;MK 0869;MK0869; ONO7436; ONO-7436; ONO 7436; L754030; L-754030; L 754030; MK-869;MK-0517; | ||
| SMILES | CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F | ||
| Chemical Name | |||
| Formula | C23H21F7N4O3 | M. Wt | 534.43 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Aprepitant is a small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors. | ||
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