NKP608
Data Sheet
For research use only. Not for human use.
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| CAS No. | 177707-12-9 | Cat. No. | BCP07461 |
| Name | NKP608 | ||
| Synonyms | NK 608; NK-608; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C31H24ClF6N3O2 | M. Wt | 620 |
| Purity | Storage | Store at 4-8°C | |
| Description | In vitro, the binding of NKP608 to bovine retina was characterized by an IC50 of 2.6+/-0.4 nM, whereas the compound's affinity to other receptor binding sites, including NK-2 and NK-3, was much lower. Species differences in IC(50) values with NKP608 were less pronounced than with previously described NK-1 receptor antagonists, being 13+/-2 and 27+/-2 nM in gerbil midbrain and rat striatum, respectively. In vivo, using the hind foot thumping model in gerbils, NKP608 exhibited a potent NK-1 antagonistic activity following oral administration (ID(50)=0.23 mg/kg; 2 h pretreatment), supporting a central activity of NKP608. NKP608 may prove a useful anxiolytic compound. | ||
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