AZ9482
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1825345-33-2 | Cat. No. | BCP20636 |
| Name | AZ9482 | ||
| Synonyms | AZ-9482; AZ 9482; | ||
| SMILES | O=C1NN=C(CC2=CC=CC(C(N3CCN(C4=NC=CC=C4C#N)CC3)=O)=C2)C5=CC=CC=C51 | ||
| Chemical Name | |||
| Formula | C26H22N6O2 | M. Wt | 450.50 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AZ9482, a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity in HeLa cells (EC50 < 18 nM). Encouragingly, AZ9482 also showed a 3 nM GI50 in the DLBCL cell line OCI-LY-19 in a 3-day AlamarBlue assay. Consistent with published siRNA knockdown experiments, AZ9482 was a 9 nM enzyme inhibitor of tankyrase 1 (TNKS1). | ||
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