Ambroxol
Data Sheet
For research use only. Not for human use.
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| CAS No. | 18683-91-5 | Cat. No. | BCP04489 |
| Name | Ambroxol | ||
| Synonyms | NA-872;NA 872;NA872; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C13H18Br2N2O | M. Wt | 378.1 |
| Purity | Storage | Store at 4-8°C | |
| Description | Ambroxol inhibits Na+ channels in sensory neurons. The potency for tonic block of TTX-r channels is relatively high. Ambroxol affects the Na+ current kinetics of TTX-r and TTX-s channels differently. In CNaIIA cells, the compound behaves like a charged local anesthetic: the block is dependent on stimulus number and increases with higher frequencies in a train of depolarizing stimuli. In CNaIIA cells, ambroxol inhibits inactivated channels 5.5-fold more potently than resting channels. The corresponding factor for TTX-r channels is only 3.3.Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. | ||
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