MCC-950 Hot

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP15729CAS No. ：210826-40-7Purity：98%

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CAS No.	210826-40-7	Cat. No.	BCP15729
Name	MCC-950
Synonyms	MCC 950;MCC950;CP-456773;CP 456773;CP456773; CRID-3; CRID3; CRID 3;
SMILES	O=S(C1=CC(C(C)(O)C)=CO1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O
Chemical Name
Formula	C20H24N2O5S	M. Wt	404.48
Purity	98%	Storage	Store at 4-8°C
Description	MCC950 , also known as CP-456773 and CRID3, is a potent and selective cytokine release inhibitor and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases. CP-456773 inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing. MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced interleukin-1β (IL-1β) production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. MCC950 is a potential therapeutic for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases, and a tool for further study of the NLRP3 inflammasome in human health and disease.