MCC950 sodium New
Data Sheet
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| CAS No. | 256373-96-3 | Cat. No. | BCP16648 |
| Name | MCC950 sodium | ||
| Synonyms | MCC 950 sodium;MCC-950 sodium;CP 45677 sodium;CP45677 sodium;CP-45677 sodium; CRID-3 sodium; CRID3 sodium; CRID 3 sodium; CP-456773 sodium salt; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C20H23N2NaO5S | M. Wt | 426.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MCC950 sodium is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.MCC950, also known as CP-456773 and CRID3, is a potent and selective cytokine release inhibitor and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases. CP-456773 inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing. MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced interleukin-1β (IL-1β) production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. MCC950 is a potential therapeutic for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases, and a tool for further study of the NLRP3 inflammasome in human health and disease. | ||
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