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GW5074 Chemical Structure

GW5074

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP06316CAS No. ：220904-83-6Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 220904-83-6 Cat. No. BCP06316
Name GW5074
Synonyms GW-5074;GW 5074;
SMILES
Chemical Name
Formula C15H8Br2INO2 M. Wt 520.94
Purity 98% Storage Store at 4-8°C
Description GW5074 is a potent and specific inhibitor of c-Raf with IC50 of 9 nM and has no effect of MKK6, MKK7, p38 MAP kinase and cdks in vitro. However, treatment of neuronal cultures with GW5074 permits accumulation of activating modifications on c-Raf and also B-Raf. The inhibition of LK-induced apoptosis by GW5074 in cerebellar granule neurons is not MEK-ERK-dependent. GW5074 delays down-regulation of Akt activity but inhibits apoptosis by an Akt-independent mechanism. GW5074 affects Ras, nuclear factor-kappa B and c-jun. GW5074 inhibits cell death caused by neurotoxins in granule cells and other neuronal types.
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