Saxagliptin

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01886CAS No. ：361442-04-8Purity：98%

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CAS No.	361442-04-8	Cat. No.	BCP01886
Name	Saxagliptin
Synonyms	BMS-477118;BMS 477118;BMS477118;Onglyza;
SMILES
Chemical Name
Formula	C18H25N3O2	M. Wt	315.41
Purity	98%	Storage	Store at 4-8°C
Description	Saxagliptin has an inhibition constant Ki of 1.3 nM for DPP4 inhibition, which is 10-fold more potent than either vildagliptin or sitagliptin (another two DPP4 inhibitors) with Ki of 13 and 18 nM. In addition, Saxagliptin demonstrates greater specificity for DPP4 than for either the DPP8 or DPP9 enzymes (400- and 75- fold, respectively). The active metablite of saxagliptin is two-fold less potent than the parent. Both Saxagliptin and its metabolite are highly selective (>4000-fold) for the prevention of DPP4 compared with a range of other proteases (selectivity of sitagliptin and vildagliptin for DPP4 is >2600 and <250-fold, respectively, compared with DPP8 and DPP9). Saxagliptin reduces the degradation of the incretin hormone glucagon-like peptide-1, thereby enhancing its actions, and is associated with improved β-cell function and suppression of glucagon secretion.