2-Hydroxyestrone New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 362-06-1 | Cat. No. | BCP46743 |
| Name | 2-Hydroxyestrone | ||
| Synonyms | 2-OHE1; 2OHE1; 2 OHE1;Catecholestrone;2-Hydroxy Estrone; | ||
| SMILES | CC12CCC3C(C1CCC2=O)CCC4=CC(=C(C=C34)O)O | ||
| Chemical Name | |||
| Formula | C18H22O3 | M. Wt | 286.37 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | 2-Hydroxyestrone is a metabolite formed during the catabolism of estrone by the liver through the hydroxylation of the carbon at position 2 by cytochrome P450 (CYP) enzymes, including CYP1A1 and 1A2, with potential anticarcinogenic activity. The mechanism of action for the antitumor activity of 2-hydroxyestrone is not known but this metabolic product has minimal estrogenic activity compared to the parent compound and other estrone metabolites. Additionally, O-methylation of this compound produces 2-methoxyestradiol (2-MeOE2), which is a potent inhibitor of both cell proliferation and angiogenesis. | ||
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