Rucaparib phosphate New
Data Sheet
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| CAS No. | 459868-92-9 | Cat. No. | BCP01731 |
| Name | Rucaparib phosphate | ||
| Synonyms | AG-014699 phosphate; PF-01367338 phosphate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H18FN3O.H3PO4 | M. Wt | 421.36 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Rucaparib Phosphate is the phosphate salt form of rucaparib, an orally bioavailable tricyclic indole and inhibitor of poly(ADP-ribose) polymerases (PARPs) 1 (PARP1), 2 (PARP2) and 3 (PARP3), with potential chemo/radiosensitizing and antineoplastic activities. Upon administration, rucaparib selectively binds to PARP1, 2 and 3 and inhibits PARP-mediated DNA repair. This enhances the accumulation of DNA strand breaks, promotes genomic instability and induces cell cycle arrest and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARPs are enzymes activated by single-strand DNA breaks that catalyze the post-translational ADP-ribosylation of nuclear proteins, which induces signaling and the recruitment of other proteins to repair damaged DNA. The PARP-mediated repair pathway plays a key role in DNA repair and is dysregulated in a variety of cancer cell types. | ||
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