Sitagliptin phosphate monohydrate New
Data Sheet
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| CAS No. | 654671-77-9 | Cat. No. | BCP01412 |
| Name | Sitagliptin phosphate monohydrate | ||
| Synonyms | Sitagliptin phosphate hydrate;MK-0431 phosphate monohydrate;Sitagliptin Phosphate.H2O; | ||
| SMILES | C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)N.O.OP(=O)(O)O | ||
| Chemical Name | |||
| Formula | C16H18F6N5O5P | M. Wt | 523.32 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Sitagliptin phosphate monohydrate is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extractsSitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It was developed and is marketed by Merck & Co. This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents (such as metformin or a thiazolidinedione) for treatment of diabetes mellitus type 2. The benefit of this medicine is its lower side-effects (e.g., less hypoglycemia, less weight gain) in the control of blood glucose values. Exenatide (Byetta) also works by its effect on the incretin system. | ||
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