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Sitagliptin phosphate Chemical Structure

Sitagliptin phosphate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP04564CAS No. :654671-78-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 654671-78-0 Cat. No. BCP04564
Name Sitagliptin phosphate
Synonyms MK-0431 phosphate;MK 0431 phosphate;MK0431 phosphate;
SMILES
Chemical Name
Formula C16H15F6N5O.H3PO4 M. Wt 505.31
Purity 98% Storage Store at 4-8°C
Description Sitagliptin phosphate is a potent inhibitor of DPP4 in Caco-2 cell extracts.As an orally active agent, Sitagliptin phosphate exhibits a potent inhibitory effect on DPP-4 with IC50 of 19 nM from Caco-2 cell extracts. MK0431 reduces in vitro migration of isolated splenic CD4 T-cells through a pathway involving cAMP/PKA/Rac1 activation.A recent study demonstrates that sitagliptin exerts a novel, direct action in order to stimulate GLP-1 secretion by the intestinal L cell through a DPP-4-independent, protein kinase A- and MEK-ERK1/2-dependent pathway. It therefore reduces the effect of autoimmunity on graft survival.
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