Linagliptin
Data Sheet
For research use only. Not for human use.
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| CAS No. | 668270-12-0 | Cat. No. | BCP02462 |
| Name | Linagliptin | ||
| Synonyms | BI 1356;Tradjenta;BI-1356;BI1356; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C25H28N8O2 | M. Wt | 472.54 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Linagliptin shows a potent inhibition effect against DPP-4 in vitro and a low affinity for hERG channel and M1 receptor (IC50 295 nM). Linagliptin acts as a competitive inhibitor with a Ki of 1 nM, and also shows 10,000-fold more selectivity for DPP-4 than DPP-8, DPP-9, amino-peptidases N and P, prolyloligopeptidase, trypsin, plasmin, and thrombin, and 90-fold more selectivity than fibroblast activation protein in vitro. | ||
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