Otenabant

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP07507CAS No. ：686344-29-6Purity：98%

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CAS No.	686344-29-6	Cat. No.	BCP07507
Name	Otenabant
Synonyms	CP 945598;CP-945598;CP945598;
SMILES
Chemical Name
Formula	C25H25Cl2N7O	M. Wt	510.42
Purity	98%	Storage	Store at 4-8°C
Description	in vitro : Otenabant (CP-945,598) exhibits sub-nanomolar potency at human CB1 receptors in both binding (Ki = 0.7 nM) and functional assays (Ki = 0.2 nM). The compound has low affinity (Ki = 7600 nM) for human CB2 receptors in vivo: Otenabant (CP-945,598) reverses four cannabinoid agonist-mediated CNS-driven responses (hypo-locomotion, hypothermia, analgesia, and catalepsy) to a synthetic cannabinoid receptor agonist. Otenabant (CP-945,598) exhibits dose and concentration-dependent anorectic activity in two models of acute food intake in rodents, fast-induced re-feeding and spontaneous, nocturnal feeding. Otenabant (CP-945,598) also acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation. CP-945,598 at 10 mg/kg promoted a 9%, vehicle adjusted weight loss in a 10 day weight loss study in diet-induced obese mice. After oral administration of a single dose of [(14)C]CP-945,598. Total mean recoveries of t