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GDC-0879 Chemical Structure

GDC-0879

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02896CAS No. ：905281-76-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 905281-76-7 Cat. No. BCP02896
Name GDC-0879
Synonyms GDC0879;GDC 0879;
SMILES
Chemical Name
Formula C19H18N4O2 M. Wt 334.37
Purity 98% Storage Store at 4-8°C
Description GDC-0879 also inhibits cellular pERK with IC50 of 63 nM. GDC-0879 shows comparable potency in A375 melanoma and Colo205 colorectal carcinoma cell lines, both of which are B-RafV600E mutant, with IC50 of 59 nM and 29 nM for pMEK1 inhibition respectively. GDC-0879 potently inhibits B-RafV600E in Malme3M cells with IC50 of 0.75 μM. GDC-0879 also shows EC50 values < 0.5 μM in many tumor cells (A375, 624, SK-MEL-28, Malme3M, C32, 928, 888, G-361, Colo205, Colo206, SW1417, CL34, and Colo201).
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