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Veliparib Chemical Structure

Veliparib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01727CAS No. ：912444-00-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 912444-00-9 Cat. No. BCP01727
Name Veliparib
Synonyms ABT-888;ABT 888;ABT888;NSC 737664;NSC-737664;NSC737664;
SMILES
Chemical Name
Formula C13H16N4O M. Wt 244.29
Purity 98% Storage Store at 4-8°C
Description Veliparib is a poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation.
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