Rolapitant hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 914462-92-3 | Cat. No. | BCP15968 |
| Name | Rolapitant hydrochloride | ||
| Synonyms | SCH619734;SCH-619734; SCH 619734; Rolapitant HCl; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C25H29ClF6N2O3 | M. Wt | 554.95 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. | ||
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