A-966492
Data Sheet
For research use only. Not for human use.
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| CAS No. | 934162-61-5 | Cat. No. | BCP01944 |
| Name | A-966492 | ||
| Synonyms | A 966492;A966492; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H17FN4O | M. Wt | 324.35 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | A-966492 displays excellent potency against the PARP-1 enzyme with a Kiof 1 nM and an EC50 of 1 nM in a whole cell assay. A-966492 significantly enhances the efficacy of TMZ in a dose-dependent manner. In addition, A-966492 is orally bioavailable across multiple species, crosses the blood?brain barrier, and appears to distribute into tumor tissue. A-966492 represents a promising, structurally diverse benzimidazole analogue and is being further characterized preclinically. | ||
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