Oprozomib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 935888-69-0 | Cat. No. | BCP07603 |
| Name | Oprozomib | ||
| Synonyms | ONX 0912; PR 047; ONX-0912; PR-047; ONX0912; PR047; | ||
| SMILES | C[C@]1(OC1)C([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC(C3=CN=C(C)S3)=O)COC)=O)COC)=O)=O | ||
| Chemical Name | |||
| Formula | C25H32N4O7S | M. Wt | 532.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ONX-0912 (as known as oprozomib), discovered during a medicinal chemistry effort using tripeptide epoxyketones, is an orally bio-available and potent proteasome inhibitor that inhibits growth and induces apoptosis in bortezomib resistant multiple myeloma (MM) cells. Although ONX-0912, an analog of carfilzomib, is structurally distinct from bortezomib, it possesses the same ability as bortezomib to predominantly inhibit chymotrypsin-like activity of the proteasome. ONX-0912 exhibits significant a | ||
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