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ONX-0914 Chemical Structure

ONX-0914

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP07652CAS No. ：960374-59-8Purity：95%
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  • Chemical Properties&Biological Activity
CAS No. 960374-59-8 Cat. No. BCP07652
Name ONX-0914
Synonyms PR957; PR-957; PR 957; ONX0914; ONX 0914;
SMILES
Chemical Name
Formula C31H40N4O7 M. Wt 580.67
Purity 95% Storage Store at 4-8°C
Description ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome. Recent evidence suggests that the immunoproteasome regulates the production of several inflammatory cytokines, including Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), IL-17, and IL-
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