BV6
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1001600-56-1 | Cat. No. | BCP10549 |
| Name | BV6 | ||
| Synonyms | BV 6;BV-6; Smac mimetic BV6; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C70H96N10O8 | M. Wt | 1205.57 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: BV6 treatment had no effect on necrotic cell death induced by poly(I:C)+IFNβ, anti-Fas+zVAD-fmk, or H2O2, but greatly sensitized cells to TNF-induced necrosis. As observed in L929 cells, BV6 treatment of FADD-deficient Jurkat cells led to a rapid loss of cIAP1 and cIAP2 and greatly sensitized these cells to TNF-induced necrosis . BV6 significantly enhances the radiosensitization of HCC193 and H460 cells in vitro . Four-hour pre-incubation with 2.5?μMol BV6 moderately enhanced CIK cell-mediated lysis of hematological (H9, THP-1, and Tanoue) and solid malignancies (RH1, RH30, and TE671). However, BV6 also increased apoptosis of non-malignant cells like peripheral blood mononuclear cells and most notably had an inhibitory effect on immune cells potentially limiting their cytotoxic potential . | ||
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