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eIF

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eIF

Chemical Structure Cat. No. Product Name CAS No.
Silvestrol Chemical Structure
 BCP33549 Silvestrol 697235-38-4
Silvestrol is a natural product found in Aglaia foveolata and Aglaia silvestris with data available.
eIF4A3-IN-1 Chemical Structure
 BCP45171 eIF4A3-IN-1 2095486-67-0
eIF4A3-IN-1 is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD.
Zotatifin Chemical Structure
 BCP35487 Zotatifin 2098191-53-6
Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM). Zotatifin induces cell apoptosis.
SBI-0640756 Chemical Structure
 BCP31598 SBI-0640756 1821280-29-8
SBI-0640756 is a first-in-class inhibitor of eIF4G1, disrupting the eIF4F complex.
BTdCPU Chemical Structure
 BCP31242 BTdCPU 1257423-87-2
BTdCPU is an activator of HRI. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma.
A 484954 Chemical Structure
 BCP28798 A 484954 142557-61-7
A 484954 is a selective inhibitor of eEF2K with IC50 value of 0.28 μM.
SBI-0640756 Chemical Structure
 BCP23633 SBI-0640756 SBI-0640756
SBI-0640756 is a water soluble inhibitor of eIF4G1 and disrupts the eIF4F complex.
Briciclib Chemical Structure
 BCP17292 Briciclib 865783-99-9
Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.
Sal003 Chemical Structure
 BCP08928 Sal003 1164470-53-4
Sal003A is a potent cell-permeable analog of the eIF2α phosphatase inhibitor .
4E1RCat Chemical Structure
 BCP14974 4E1RCat 328998-25-0
4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.
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