GSK 1562590 hydrochloride New
Data Sheet
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| CAS No. | 1003878-07-6 | Cat. No. | BCP28084 |
| Name | GSK 1562590 hydrochloride | ||
| Synonyms | GSK 1562590 HCl;GSK-1562590 HCl;GSK1562590 HCl;GSK-1562590 hydrochloride;GSK1562590 hydrochloride; | ||
| SMILES | CN(C(CN1CCCC1)C2=CC=C(C=C2)C3=CC(=CC=C3)C(=O)N)C(=O)CN4C(=O)COC5=CC(=C(C=C54)Cl)Cl.Cl | ||
| Chemical Name | |||
| Formula | C30H30Cl2N4O4.HCl | M. Wt | 617.95 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GSK 1562590 hydrochloride is a high affinity and selective urotensin II (UT) receptor antagonist (pKi values are 9.14, 9.28, 9.34, 9.64 and 9.66 at monkey, human, mouse, cat and rat recombinant receptors respectively). Exhibits selectivity for UT receptors over a range of GPCRs, ion channels, enzymes and neurotransmitter transporters. Supresses human urotensin-II (hU-II)-induced contraction of isolated rat aorta in vitro and ex vivo. Inhibits the hU-II-induced increase in mean blood pressure in vivo. | ||
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