Ivacaftor hydrate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1134822-07-3 | Cat. No. | BCP14735 |
| Name | Ivacaftor hydrate | ||
| Synonyms | VX-770 hydrate;VX 770 hydrate;VX770 hydrate;Kalydeco hydrate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H30N2O4 | M. Wt | 410.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: In recombinant cells VX-770 increased CFTR channel open probability (P(o)) in both the F508del processing mutation and the G551D gating mutation. VX-770 also increased Cl(-) secretion in cultured human CF bronchial epithelia (HBE) carrying the G551D gating mutation on one allele and the F508del processing mutation on the other allele by approximately 10-fold, to approximately 50% of that observed in HBE isolated from individuals without CF. in vivo: At day 28, in the group of subjects who received 150 mg of VX-770, the median change in the nasal potential difference (in response to the administration of a chloride-free isoproterenol solution) from baseline was -3.5 mV (range, -8.3 to 0.5; P=0.02 for the within-subject comparison, P=0.13 vs. placebo), and the median change in the level of sweat chloride was -59.5 mmol per liter (range, -66.0 to -19.0; P=0.008 within-subject, P=0.02 vs. placebo). Toxicity: Six severe adverse events occurred in two subjects (diffuse macular rash | ||
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