EMD638683 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1181770-72-8 | Cat. No. | BCP29409 |
| Name | EMD638683 | ||
| Synonyms | EMD 638683; EMD-638683; | ||
| SMILES | CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O | ||
| Chemical Name | |||
| Formula | C18H18F2N2O4 | M. Wt | 364.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | EMD638683 is a potent inhibitor of SGK1 with an IC50 value of 3 μM. EMD638683 treatment significantly augmented the radiation-induced decrease of forward scatter, increase of phosphatidylserine exposure, decrease of mitochondrial potential, increase of caspase 3 activity, increase of DNA fragmentation and increase of late apoptosis. EMD638683 promotes radiation-induced suicidal death of colon tumor cells in vitro and decreases the number of colonic tumors following chemical carcinogenesis in vivo. | ||
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