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Nelarabine
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CAS No. | 121032-29-9 | Cat. No. | BCP02093 |
Name | Nelarabine | ||
Synonyms | Arranon;506U7; | ||
SMILES | |||
Chemical Name | |||
Formula | C11H15N5O5 | M. Wt | 297.27 |
Purity | 98% | Storage | Store at 4-8°C |
Description | The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively.Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells.Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity. |
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