GKT137831 New
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Publications Citing of Biochempartner's GKT137831
| CAS No. | 1218942-37-0 | Cat. No. | BCP14159 |
| Name | GKT137831 | ||
| Synonyms | GKT-137831;GKT 137831; GTK831; GTK-831; GTK 831;Setanaxib; | ||
| SMILES | CN1C(=O)C=C2C(=C1C3=CC(=CC=C3)N(C)C)C(=O)N(N2)C4=CC=CC=C4Cl | ||
| Chemical Name | |||
| Formula | C21H19ClN4O2 | M. Wt | 394.85 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GKT137831 is a novel and potent Nox4 inhibitor. GKT137831 reduced the increased leukocyte adherence to the vasculature, the pro-inflammatory phenotype of microglia and macroglia, the increased gene and protein expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and leukocyte adhesion molecules as well as vascular leakage. In all cultured cell types, GKT137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators. GKT137831 may be potentially useful as a treatment for a variety of vision-threatening retinopathies. | ||
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