Mps1-in-2
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1228817-38-6 | Cat. No. | BCP19164 |
| Name | Mps1-in-2 | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C26H36N6O3 | M. Wt | 480.6 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Mps1-IN-2 inhibited Mps1 kinase activity with half-maximal inhibitory concentrations (IC50) of 3145 nM when screened at 1 μM ATP (apparent Km for ATP < 1 μM). Both compounds demonstrated greater than 1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk for Mps1-IN-1 and Gak and Plk1 for Mps1-IN-2. The M602Q Mps1 mutant was 5 and 19-fold less sensitive to Mps1-IN-1 and Mps1-IN-2 respectively. | ||
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