Losartan Carboxylic Acid
Data Sheet
For research use only. Not for human use.
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| CAS No. | 124750-92-1 | Cat. No. | BCP08038 |
| Name | Losartan Carboxylic Acid | ||
| Synonyms | EXP-3174; EXP 3174; EXP3174; E-3174; E 3174; E3174; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H21ClN6O2 | M. Wt | 436.89 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | EXP-3174, also known as Losartan Carboxylic Acid, is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. Like the parent compound, EXP-3174 is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability. | ||
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